Journal of Digestive Cancer Research 2020; 8(2): 77-80
Published online December 31, 2020
© Korean Society of Gastrointestinal Cancer
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. The increased expression of cyclooxygenase (COX)-2 has been implicated in the development and progression of gastric cancers. A number of recent studies have been published evaluating the chemopreventive effect of aspirin and non steroidal anti inflammatory drungs (NSAIDs) against gastric cancer. Aspirin and NSAIDs use may reduce the risk of gastric cancer incidence and death, whereas other studies have reported contradictory results. Therefore, further study should be needed to clarify the role of aspirin and NSAIDs in the chemoprevention of gastric cancer.
KeywordsAnti-inflammatory agents Non-steroidal Aspirin Chemoprevention Low-dose Stomach neoplasia
Journal of Digestive Cancer Research 2020; 8(2): 77-80
Published online December 31, 2020
Copyright © Korean Society of Gastrointestinal Cancer Research.
김연지, 정우철
가톨릭대학교 의과대학 내과학교실 성빈센트병원 소화기내과
Yeon-Ji Kim, Woo Chul Chung
Department of Internal Medicine, St. Vincent’s Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. The increased expression of cyclooxygenase (COX)-2 has been implicated in the development and progression of gastric cancers. A number of recent studies have been published evaluating the chemopreventive effect of aspirin and non steroidal anti inflammatory drungs (NSAIDs) against gastric cancer. Aspirin and NSAIDs use may reduce the risk of gastric cancer incidence and death, whereas other studies have reported contradictory results. Therefore, further study should be needed to clarify the role of aspirin and NSAIDs in the chemoprevention of gastric cancer.
Keywords: Anti-inflammatory agents, Non-steroidal, Aspirin, Chemoprevention, Low-dose, Stomach neoplasia