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Review Article

Journal of Digestive Cancer Research 2020; 8(1): 56-60

Published online June 30, 2020

© Korean Society of Gastrointestinal Cancer

대장암에서 액체 생검의 역할

Role of Liquid Biopsies in Colorectal Cancer

김상현, 금보라
Sang Hyun Kim, Bora Keum


고려대학교 의과대학 내과학교실, 고려대학교 안암병원 소화기내과
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea

Abstract

In recent years, liquid biopsy has received immense attention. Liquid biopsy is a minimally invasive method used for obtaining biological fluids including urine, pleural fluid and, mostly, peripheral blood. Liquid biopsy involves various targets including circulating tumors cells (CTCs), circulating cell‐free tumor DNA (ctDNA), and microRNA (miRNA). Colorectal cancer (CRC), like other solid tumors, shed tumor cells into the bloodstream. Analysis of these CTCs, as well as ctDNA is the primary objective of the liquid biopsy. Evaluation of CTC or ctDNA offers information about early tumor release, development of tumor metastasis and also about mechanisms involved in tumor resistance to treatment.

KeywordsCirculating Tumor cell Colorectal cancer ctDNA Liquid biopsy

Article

Review Article

Journal of Digestive Cancer Research 2020; 8(1): 56-60

Published online June 30, 2020

Copyright © Korean Society of Gastrointestinal Cancer Research.

대장암에서 액체 생검의 역할

김상현, 금보라

고려대학교 의과대학 내과학교실, 고려대학교 안암병원 소화기내과

Role of Liquid Biopsies in Colorectal Cancer

Sang Hyun Kim, Bora Keum

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea

Abstract

In recent years, liquid biopsy has received immense attention. Liquid biopsy is a minimally invasive method used for obtaining biological fluids including urine, pleural fluid and, mostly, peripheral blood. Liquid biopsy involves various targets including circulating tumors cells (CTCs), circulating cell‐free tumor DNA (ctDNA), and microRNA (miRNA). Colorectal cancer (CRC), like other solid tumors, shed tumor cells into the bloodstream. Analysis of these CTCs, as well as ctDNA is the primary objective of the liquid biopsy. Evaluation of CTC or ctDNA offers information about early tumor release, development of tumor metastasis and also about mechanisms involved in tumor resistance to treatment.

Keywords: Circulating Tumor cell, Colorectal cancer, ctDNA, Liquid biopsy

Journal Info

JDCR
Vol.12 No.1
April 20, 2024
eISSN : 2950-9505
pISSN : 2950-9394
Frequency: Triannual

open access

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Journal of Digestive Cancer Research

eISSN 2950-9505
pISSN 2950-9394

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  • 2024