Journal of Digestive Cancer Research 2020; 8(1): 56-60
Published online June 30, 2020
© Korean Society of Gastrointestinal Cancer
In recent years, liquid biopsy has received immense attention. Liquid biopsy is a minimally invasive method used for obtaining biological fluids including urine, pleural fluid and, mostly, peripheral blood. Liquid biopsy involves various targets including circulating tumors cells (CTCs), circulating cell‐free tumor DNA (ctDNA), and microRNA (miRNA). Colorectal cancer (CRC), like other solid tumors, shed tumor cells into the bloodstream. Analysis of these CTCs, as well as ctDNA is the primary objective of the liquid biopsy. Evaluation of CTC or ctDNA offers information about early tumor release, development of tumor metastasis and also about mechanisms involved in tumor resistance to treatment.
KeywordsCirculating Tumor cell Colorectal cancer ctDNA Liquid biopsy
Journal of Digestive Cancer Research 2020; 8(1): 56-60
Published online June 30, 2020
Copyright © Korean Society of Gastrointestinal Cancer Research.
김상현, 금보라
고려대학교 의과대학 내과학교실, 고려대학교 안암병원 소화기내과
Sang Hyun Kim, Bora Keum
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea
In recent years, liquid biopsy has received immense attention. Liquid biopsy is a minimally invasive method used for obtaining biological fluids including urine, pleural fluid and, mostly, peripheral blood. Liquid biopsy involves various targets including circulating tumors cells (CTCs), circulating cell‐free tumor DNA (ctDNA), and microRNA (miRNA). Colorectal cancer (CRC), like other solid tumors, shed tumor cells into the bloodstream. Analysis of these CTCs, as well as ctDNA is the primary objective of the liquid biopsy. Evaluation of CTC or ctDNA offers information about early tumor release, development of tumor metastasis and also about mechanisms involved in tumor resistance to treatment.
Keywords: Circulating Tumor cell, Colorectal cancer, ctDNA, Liquid biopsy