Gallbladder (GB) cancer is highly malignant neoplasm found in advanced stage and chemotherapy commonly plays
a palliative role in GB cancer. We report a case of unresectable GB cancer treated with chemotherapy followed by
extended cholecystectomy. Fifty-six-year-old male visited our hospital with weight loss and dyspnea on exertion. Computed
tomography detected pulmonary embolism and diffuse GB wall thickening with para-aortic lymph node enlargement.
The length of common channel was 23mm at magnetic resonance cholangiopancreatography which stands for
anomalous union of the pancreaticobiliary duct. Anticoagulation was started for pulmonary embolism. GB wall mass
was regarded as unresectable GB cancer with distant lymph node metastasis. Gemcitabine and cisplatin combination
chemotherapy was carried out for 6 cycles. Primary tumor was stationary but multiple enlarged lymphnodes were
almost completely disappeared. Extended cholecystectomy with hepaticojejunostomy was performed. Post-operative
tumor stage was T3N1 (stage IIIB) and R0 resection was achieved. After operation he has no evidence of disease
recurrence for 6 months.

Keywords: Gallbladder neoplasms, Drug therapy, Cholecystectomy, Gemcitabine, Cisplatin